Methanol → HCID 178501119, compound

Participants

Reaction Steps

Thionyl chloride (7 ml, 96 mmol) was added to a solution of trans-4-aminomethyl cyclohexanecarboxylic acid (5.00 g, 31.8 mmol) in methanol (50 ml) and the mixture was stirred at room temperature for 16 hours. The reaction solution was concentrated and the obtained solid was washed with diethyl ether (50 ml). Trans-4-aminomethylcyclohexanecarboxylic acid methyl ester hydrochloride (6.49 g, 98%) was obtained by separating by filtration and drying in vacuo.

Provenance & Evidence