Hydrochloric Acid → HCID 178428572, compound

Participants

Reaction Steps

A solution of trans-4-[(N-methyl-N-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}amino)methyl]cyclohexanecarboxylic acid methyl ester (217 mg, 0.48 mmol) obtained in Step 5, 1N aqueous sodium hydroxide (2 ml, 2 mmol) in methanol (2 ml) and tetrahydrofuran (2 ml) was stirred at room temperature for 16 hours. The solution was neutralized with 1N hydrochloric acid and extracted with chloroform (50 ml×2). The organic layer was washed with a saturated brine (20 ml) and dried over magnesium sulfate and filtrated and vacuum concentrated. The solid obtained by adding chloroform-diethyl ether (1:1) (10 ml) to the residue was collected by filtration, dried in vacuo and thereby trans-4-[(N-methyl-N-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}amino)methyl]cyclohexanecarboxylic acid (190 mg, 90%) was obtained.

Provenance & Evidence