Water → HCID 58706888, compound

Participants

Reaction Steps

3M-Methylmagnesium bromide ether solution (0.19 ml, 0.57 mmol) was added to a solution of 5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiophene-2-carboaldehyde (70 mg, 0.24 mmol) in tetrahydrofuran (4 ml) cooled with ice, and after that the mixture was stirred at room temperature for 3 hours in an Ar stream. Water was added to the reaction solution and the solution was extracted with ethyl acetate and the organic layer was washed with a saturated brine and dried over anhydrous magnesium sulfate. Subsequently, the residue obtained by concentration in vacuo was washed with isopropyl ether, dried in vacuo and the title compound (46 mg, 62%) was obtained.

Provenance & Evidence