HCID 68513323, compound → HCID 68512476, compound

Participants

Reaction Steps

A mixture of racemic 1-Boc-trans-3-hydroxy-4-(4-methyl-2-nitro-phenylamino)-piperidine (15.0 g, 42.6 mmol) and 10% Pd on carbon (1.5 g, 10% by weight) in ethanol (280 mL) was stirred under 1 atm of H2 gas for 17 h. The solid catalyst was then removed by filtration through Celite and all volatiles were removed under reduced pressure to yield the product, racemic 1-Boc-trans-4-(2-amino-4-methyl-phenylamino)-3-hydroxy-piperidine as a heavy oil (14.1 g, quant).

Provenance & Evidence