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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716669Generated: October 25, 2026

5-Bromo-3-cyanoindole → 3-(3-Cyano-1H-Indol-5-yl)-3-phenyl-acrylic acid ethyl ester

https://huagongshe.com/reaction/1716669

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-3-cyanoindoleHCID 3623354—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Product3-(3-Cyano-1H-Indol-5-yl)-3-phenyl-acrylic acid ethyl esterHCID 6735613185%

Reaction Steps

3-(3-Cyano-1H-Indol-5-yl)-3-phenyl-acrylic acid ethyl ester LXIII (1.82 g, 85% yield) was prepared from 5-bromo-1H-indole-3-carbonitrile using the procedure described for 3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803830B2
Source datasetuspto-grants-2010_09
ORD IDord-1521138748dd48c09fbf2987157e8f04
Source noteuspto-grants-2010_09