3-(2-Methyl-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester → N-Methyl-3-(2-methyl-1H-indol-5-yl)-3-phenyl-acrylamide

HRID 1716674Notes

Reaction equation

HRID 1716674 reaction equation
C(O[C:4](=[O:23])[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]([CH3:22])=[CH:16]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.[NH:24]1C2C(=CC=CC=2C(C2C=CC=CC=2)=CC(NC)=O)C=[CH:25]1>>[CH3:25][NH:24][C:4](=[O:23])[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]([CH3:22])=[CH:16]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 673551423-(2-Methyl-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl esterHCID 691740993-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide

Product 1

HCID 67356049N-Methyl-3-(2-methyl-1H-indol-5-yl)-3-phenyl-acrylamide

Procedure

N-Methyl-3-(2-methyl-1H-indol-5-yl)-3-phenyl-acrylamide LXVIII (990 mg, 83%) was prepared from 3-(2-methyl-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described for 3-(1H-indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-0a5727609d89424db11dae1fd707b835
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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