HCID 67356265, compound → HCID 67356444, compound

HRID 1716686Notes

Reaction equation

HRID 1716686 reaction equation
C([O:3][C:4](=O)[CH2:5][CH:6]([C:13]1[CH:14]=[C:15]2[C:19](=[C:20]([F:22])[CH:21]=1)[NH:18][CH:17]=[C:16]2[C:23]#[N:24])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.OCCC(N1C2C(=CC=CC=2)C(C#N)=C1)C1C=CC=CC=1>>[F:22][C:20]1[CH:21]=[C:13]([CH:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:5][CH2:4][OH:3])[CH:14]=[C:15]2[C:19]=1[NH:18][CH:17]=[C:16]2[C:23]#[N:24]

Participants

3

Reactant 2

HCID 67356265HCID 67356265, compoundHCID 86612754HCID 86612754, compound

Product 1

HCID 67356444HCID 67356444, compound

Procedure

7-Fluoro-5-(3-hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile LXXXVIII (328 mg) was prepared from 3-(3-cyano-7-fluoro-1H-indol-5-yl)-3-phenyl-propionic acid ethyl ester using the procedure described above for preparation of -(3-Hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile LX (Example 14).

Sources & evidence

ORD record
ord-2abcc7e903e845398e3dc2ae1f2acff7
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

Loading…