6-Bromo-5-methoxy-1H-indole → 3-(5-Methoxy-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

HRID 1716698Notes

Reaction equation

HRID 1716698 reaction equation
BrC1C=C2C(C=CN2)=CC=1OC.[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18]([C:25]1[C:33]([O:34][CH3:35])=[CH:32][CH:31]=[C:30]2[C:26]=1[CH:27]=[CH:28][NH:29]2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18]([C:25]1[CH:26]=[C:30]2[C:31]([CH:27]=[CH:28][NH:29]2)=[CH:32][C:33]=1[O:34][CH3:35])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH3:14]

Participants

3

Reactant 2

HCID 145465856-Bromo-5-methoxy-1H-indoleHCID 673557843-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673566903-(5-Methoxy-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

Procedure

3-(5-Methoxy-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CXXXIII was prepared from 6-bromo-5-methoxyindole XLVII using the procedure described above for preparation of 3-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester XLVIII (Example 12).

Sources & evidence

ORD record
ord-d3705754511e4dfca45d3dca2655ab12
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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