3-(3-cyano-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester → 3-(5-Methoxy-1H-indol-6-yl)-3-phenyl-propionic acid ethyl ester

HRID 1716699Notes

Reaction equation

HRID 1716699 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]=[C:6]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][NH:19]2)=[CH:15][C:14]=1[O:22][CH3:23])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].C(OC(=O)CC(C1C=CC=C2C=1C(C#N)=CN2)C1C=CC=CC=1)C>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][NH:19]2)=[CH:15][C:14]=1[O:22][CH3:23])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 673560383-(3-cyano-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl esterHCID 673566903-(5-Methoxy-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 598317333-(5-Methoxy-1H-indol-6-yl)-3-phenyl-propionic acid ethyl ester

Procedure

3-(5-Methoxy-1H-indol-6-yl)-3-phenyl-propionic acid ethyl ester CXXXIV was prepared from 3-(5-methoxy-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described above for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester LIX (Example 14)

Sources & evidence

ORD record
ord-8d9a062597d34da494af8bd21c847b67
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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