HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 5-Bromo-2-oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Bromo-2-oxindole | HCID 611193 | 87% |
Reaction Steps
A suspension of 1,3-dihydro-indol-2-one (1.3 g, 9.76 mmol) in acetonitrile (20 mL) at −5° C. was treated with N-bromosuccinimide, warmed to room temperature, stirred overnight and filtered to give 1.8 g (87% yield) of the desired product. MS (ESI(+)) m/e 209.9, 211.9 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737160B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-0d6af9dc736d4364b96547b8d6772231 |
| Source note | uspto-grants-2010_06 |