3-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide → 3-(3-Cyano-1H-indol-6-yl)-3-phenyl-propionic acid ethyl ester

HRID 1716712Notes

Reaction equation

HRID 1716712 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]=[C:6]([C:13]1[CH:21]=[C:20]2[C:16]([C:17]([C:22]#[N:23])=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].N1C2C(=CC=CC=2C(C2C=CC=CC=2)CC(NC)=O)C=C1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([C:17]([C:22]#[N:23])=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 598317453-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamideHCID 673557733-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673566883-(3-Cyano-1H-indol-6-yl)-3-phenyl-propionic acid ethyl ester

Procedure

3-(3-Cyano-1H-indol-6-yl)-3-phenyl-propionic acid ethyl ester CLIII was prepared from 3-(3-cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described above for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide XIX (Example 4).

Sources & evidence

ORD record
ord-78ab967592da478e86a44e4d162e92f3
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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