Ethyl 3-(pyridin-2-yl)acrylate → HCID 67377079, compound

HRID 1716719Notes

Reaction equation

HRID 1716719 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH2:13]([O:15][C:16](=[O:25])[CH:17]=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)[CH3:14].C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=CN2)C1C=CC=CC=1)C>>[CH2:13]([O:15][C:16](=[O:25])[CH:17]=[C:18]([C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)[CH3:14]

Participants

4

Reactant 3

HCID 370265Ethyl 3-(pyridin-2-yl)acrylateHCID 114700676-Bromo-1H-indole-3-carbonitrileHCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 67377079HCID 67377079, compound

Procedure

3-(3-Cyano-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester CLXX was prepared from 6-bromo-1H-indole-3-carbonitrile (CLI) and 3-pyridin-2-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Sources & evidence

ORD record
ord-cb512664212a4242824ca5edee643a8d
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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