3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester → 6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile

HRID 1716720Notes

Reaction equation

HRID 1716720 reaction equation
C([O:3][C:4](=O)[CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([C:17]([C:22]#[N:23])=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)C.OCCC(C1C=CC=C2C=1C(C#N)=CN2)C1C=CC=CC=1>>[OH:3][CH2:4][CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([C:17]([C:22]#[N:23])=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

Participants

3

Reactant 2

HCID 673568523-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl esterHCID 673762644-(3-hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile

Product 1

HCID 673562686-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile

Procedure

6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile CLXXII was prepared from 3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester using the procedure described for preparation of 4-(3-Hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile LX (Example 14).

Sources & evidence

ORD record
ord-247b0d6e23eb45099521636cebbd44ae
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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