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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716721Generated: October 30, 2026

Ethyl 3-(pyridin-2-yl)acrylate → 3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester

https://huagongshe.com/reaction/1716721

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(pyridin-2-yl)acrylateHCID 370265—
Reactant6-Bromo-4-methoxy-1H-indoleHCID 24728034—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Product3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl esterHCID 67355594—

Reaction Steps

3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester CLXXIV was prepared from 4-methoxy-6-bromo-1H-indole and 3-pyridin-2-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803830B2
Source datasetuspto-grants-2010_09
ORD IDord-472a407280cb482a9fd308d04afba890
Source noteuspto-grants-2010_09