3-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide → 3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester

HRID 1716722Notes

Reaction equation

HRID 1716722 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]=[C:6]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][NH:19]2)=[C:15]([O:22][CH3:23])[CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:2].N1C2C(=CC=CC=2C(C2C=CC=CC=2)CC(NC)=O)C=C1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH:6]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][NH:19]2)=[C:15]([O:22][CH3:23])[CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 598317453-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamideHCID 673555943-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester

Product 1

HCID 598318403-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester

Procedure

3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester CLXXV was prepared from 3-(4-methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide XIX (Example 4).

Sources & evidence

ORD record
ord-1a5f80e19fd1491dacd488747cb019cb
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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