3-(3-Methoxy-1H-indazol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(3-Methoxy-1H-indazol-4-yl)-N-methyl-3-phenyl-acrylamide

HRID 1716733Notes

Reaction equation

HRID 1716733 reaction equation
C([O:3][C:4](=O)[CH:5]=[C:6]([C:13]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:14]=1[C:15]([O:22][CH3:23])=[N:16][NH:17]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:40][NH:41]2)C1C=CC=CC=1)C>>[CH3:23][O:22][C:15]1[C:14]2[C:18](=[CH:19][CH:20]=[CH:21][C:13]=2[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([NH:41][CH3:40])=[O:3])[NH:17][N:16]=1

Participants

3

Reactant 2

HCID 673552033-(3-Methoxy-1H-indazol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673554123-(3-Methoxy-1H-indazol-4-yl)-N-methyl-3-phenyl-acrylamide

Procedure

3-(3-Methoxy-1H-indazol-4-yl)-N-methyl-3-phenyl-acrylamide CLXXXVIII was prepared from 3-(3-methoxy-1H-indazol-4-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-68583bd71cf44070a8213a91733a19b8
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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