3-(3-methoxy-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester → 3-(3-Methoxy-1H-indazol-5-yl)-N-methyl 3-phenyl-acrylamide

HRID 1716747Notes

Reaction equation

HRID 1716747 reaction equation
C([O:3][C:4](=O)[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][N:17]=[C:16]2[O:22][CH3:23])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:40][NH:41]2)C1C=CC=CC=1)C>>[CH3:23][O:22][C:16]1[C:15]2[C:19](=[CH:20][CH:21]=[C:13]([C:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[CH:5][C:4]([NH:41][CH3:40])=[O:3])[CH:14]=2)[NH:18][N:17]=1

Participants

3

Reactant 2

HCID 673551473-(3-methoxy-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl esterHCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673566793-(3-Methoxy-1H-indazol-5-yl)-N-methyl 3-phenyl-acrylamide

Procedure

The amide compound CCXII was prepared from 3-(3-methoxy-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-7a5b733970034fa6bc0db5d911eb7c00
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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