3-Pyridineacrylic acid ethyl ester → HCID 178470958, compound

HRID 1716754Notes

Reaction equation

HRID 1716754 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[Cl:11].[CH2:12]([O:14][C:15](=[O:24])[CH:16]=[CH:17][C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH:16]=[C:17]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[Cl:11])[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:13]

Participants

3

Reactant 2

HCID 5833373-Pyridineacrylic acid ethyl esterHCID 178478419HCID 178478419, compound

Product 1

HCID 178470958HCID 178470958, compound

Procedure

3-(3-Chloro-1H-indazol-5-yl)-3-pyridin-3-yl-acrylic acid ethyl ester CCXXIII was prepared from 5-bromo-3-chloro-1H-indazole and 3-pyridin-3-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterLVIII (Example 14).

Sources & evidence

ORD record
ord-4a10ca1adafc4d388cb0263efd0b5e71
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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