3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → HCID 178485655, compound

HRID 1716755Notes

Reaction equation

HRID 1716755 reaction equation
C(O[C:4](=[O:23])[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][N:17]=[C:16]2[Cl:22])[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:39][NH:40]2)C1C=CC=CC=1)C>>[Cl:22][C:16]1[C:15]2[C:19](=[CH:20][CH:21]=[C:13]([C:6]([C:7]3[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=3)=[CH:5][C:4]([NH:40][CH3:39])=[O:23])[CH:14]=2)[NH:18][N:17]=1

Participants

3

Reactant 2

HCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 178470958HCID 178470958, compound

Product 1

HCID 178485655HCID 178485655, compound

Procedure

3-(3-Chloro-1H-indazol-5-yl)-N-methyl 3-pyridin-3-yl-acrylamide CCXXIV was prepared from 3-(3-chloro-1H-indazol-5-yl)-3-pyridin-3-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-3b93570f9a7c498cb03e5093bd586ba5
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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