2-Amino-4-bromobenzoic acid → 6-Bromo-1,2-dihydro-3H-indazol-3-one

HRID 1716760Notes

Reaction equation

HRID 1716760 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]([OH:11])=O)=[C:6]([CH:8]=1)[NH2:7].BrC1C=CC=C2C=1C(O)=[N:16]N2>>[Br:1][C:2]1[CH:8]=[C:6]2[C:5]([C:9]([OH:11])=[N:16][NH:7]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 886912-Amino-4-bromobenzoic acidHCID 178518956HCID 178518956, compound

Product 1

HCID 1785189546-Bromo-1,2-dihydro-3H-indazol-3-one

Procedure

6-Bromo-1H-indazol-3-ol CCVII was prepared from 5-bromo-2-carboxyaniline (JOC, 1997, 62, 1240) using the procedure described for preparation of 4-Bromo-1H-indazol-3-ol CLXXXIII (Example 37).

Sources & evidence

ORD record
ord-d7711fe1ee20416eb370bd5cb82417e8
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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