6-Bromo-3-methoxy-1H-indazole → 3-(3-Methoxy-1H-indazol-6-yl)-3-(6-methyl-pyridin-2-yl)-acrylic acid ethyl ester

HRID 1716772Notes

Reaction equation

HRID 1716772 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:11][CH3:12])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[CH2:13]([O:15][C:16](=[O:26])[CH:17]=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:26])[CH:17]=[C:18]([C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:11][CH3:12])=[N:7][NH:8]2)=[CH:4][CH:3]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=1)[CH3:14]

Participants

3

Reactant 2

HCID 598318906-Bromo-3-methoxy-1H-indazoleHCID 673561473-(6-Methylpyridin-2-yl)acrylic acid ethyl ester

Product 1

HCID 673560733-(3-Methoxy-1H-indazol-6-yl)-3-(6-methyl-pyridin-2-yl)-acrylic acid ethyl ester

Procedure

3-(3-Methoxy-1H-indazol-6-yl)-3-(6-methyl-pyridin-2-yl)-acrylic acid ethyl ester CCLIII was prepared from 6-bromo-3-methoxy-1H-indazole and 3-(6-methyl-pyridin-2-yl)-acrylic acid ethyl ester using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterLVIII (Example 14).

Sources & evidence

ORD record
ord-4b4d2329640d40d882858126c67f8e89
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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