L-Serine, methyl ester, hydrochloride (1:1) → HCID 68666250, compound

HRID 1716837Notes

Reaction equation

HRID 1716837 reaction equation
[N:1]1([C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.Cl.[CH3:21][O:22][C:23](=[O:28])[C@H:24]([CH2:26][OH:27])[NH2:25]>>[N:1]1([C:10]2[CH:11]=[CH:12][C:13]([C:14]([NH:25][C@H:24]([C:23]([O:22][CH3:21])=[O:28])[CH2:26][OH:27])=[O:16])=[CH:18][CH:19]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 2723730L-Serine, methyl ester, hydrochloride (1:1)HCID 5328451HCID 5328451, compound

Product 1

HCID 68666250HCID 68666250, compound

Procedure

Using essentially the same procedures described in Example 1, step 2, and Example 2, and employing methyl 4-(1H-benzimidazol-1-yl)benzoate and serine methyl ester HCl as reactants, the title compound was obtained and identified by NMR and mass spectral analyses. 1H NMR (400 MHz, DMSO-d6): 8.12 (s, 1H), 8.05 (d, J=7.2 Hz, 2H), 7.88-7.90 (m, 1H), 7.69-7.71 (m, 1H), 7.60 (d, J=7.2 Hz, 2H), 7.51-7.57 (m, 2H) 7.36-7.38 (m, 2H), 7.22-7.24 (m, 1H), 4.92-4.94 (m, 1H), 4.10-4.23 (m, 4H), 3.86 (s, 3H), 3.6 (s, 3H). LCMS (ESI+) 340 (MH+).

Sources & evidence

ORD record
ord-eefb7b2e92cb4ee582565cf2f7493010
Source dataset
uspto-grants-2010_09
Patent number
US07803825B2

Reaction notes

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