Potassium Carbonate → HCID 57550235, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl {2-[4-(1H-benzimidazol-2-yl)phenyl]-1,3-oxazol-4-yl}carboxylate (200 mg, 0.62 mmol), bromomethylcyclobutane (140 mg, 0.94 mmol) and K2CO3 (103 mg, 0.75 mmol) in dry acetonitrile was heated to 120° C. with microwave irradiation for 1.5 h. The reaction mixture was cooled to room temperature and concentrated in vacuo. The resultant residue was dissolved in CH2Cl2, washed with water, dried over Na2SO4 and evaporated to dryness under reduced pressure. This residue was purified by column chromatography (silica, CH2Cl2:MeOH 98:2) to afford the title compound in 54% yield, identified by NMR and mass spectral analyses. LCMS (ESI+) 388 (MH+).

Provenance & Evidence