1,3-Dichloroacetone → HCID 57550208, compound

Participants

Reaction Steps

A stirred solution of 4-(1H-benzimidazol-1-ylmethyl)benzenecarbo-thioamide (0.50 g, 1.87 mmol) in ethanol was treated with 1,3-dichloroacetone (0.235 g, 1.85 mmol), heated at reflux temperature for 3 h, allowed to cool to room temperature and filtered. The filtercake was washed with cold ethanol and dried under vacuum to afford the title compound in 60% yield, identified by NMR and mass spectral analyses. 1H NMR (400 MHz, CDCl3): 4.85 (s, 2H), 5.67 (s, 2H), 7.34-7.35 (m, 2H), 7.48 (d, J=7.6 Hz, 2H), 7.64-7.65 (m, 1H), 7.74-7.76 (m, 1H), 7.80 (s, 1H), 7.92 (d, J=7.6 Hz, 2H), 8.94 (s, 1H). LCMS (ESI+) 340 (MH+).

Provenance & Evidence