HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-[4-(Hydroxymethyl)phenyl]-1,3-oxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl 2-[4-(hydroxymethyl)phenyl]-1,3-oxazole-4-carboxylate | HCID 46834789 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[4-(Hydroxymethyl)phenyl]-1,3-oxazole-4-carboxylic acid | HCID 57550193 | 91% |
Reaction Steps
A solution of ethyl 2-[4-(hydroxymethyl)phenyl]-1,3-oxazole-4-carboxylate (2.5 g, 10.1 mmol) in 1:1 MeOH:THF was treated with 1.0 M LiOH:H2O and stirred at room temperature overnight and concentrated in in vacuo. The resulting residue was diluted with water, treated with 1.0 M HCl and filtered to afford the title product 91% yield, identified by NMR and mass spectral analyses. LCMS (ESI+) 219 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803825B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-6a72186a4c8346eea6a8aa93cb2b02fb |
| Source note | uspto-grants-2010_09 |