Aluminium lithium hydride → HCID 57550203, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium aluminum hydride (60.8 mg, 1.6 mmol) in anhydrous tetrahydrofuran (4 mL) under nitrogen cooled to −5° C. was added dropwise a solution of 2-(4-benzoimidazol-1-ylmethyl-phenyl)-3-methyl-3H-imidazole-4-carboxylic acid methyl ester (280 mg, 0.8 mmol) in anhydrous tetrahydrofuran (2 mL) over 10 min and the reaction mixture was allowed to stir at for 1 h. The reaction mixture was quenched with water (0.06 mL), aqueous sodium hydroxide (2.5 N, 0.21 mL), and again water (0.06 mL), stirred for 30 min, then diluted with tetrahydrofuran (20 mL) and left overnight without stirring. The reaction mixture was diluted with dichloromethane (20 mL) and methanol (20 mL) and the solid was filtered off. The filtrate was evaporated under reduced pressure and the crude product was used in the next step without further purification. LCMS (ESI+) 319.2 (MH+).

Provenance & Evidence