Isobutylamine → (1-Benzyl-2-hydroxy-3-isobutylaminopropyl)carbamic acid tert-butyl ester

HRID 1716870Notes

Reaction equation

HRID 1716870 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][CH:8]([CH:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:20]([NH2:24])[CH:21]([CH3:23])[CH3:22]>>[C:1]([O:5][C:6](=[O:19])[NH:7][CH:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH:16]([OH:17])[CH2:18][NH:24][CH2:20][CH:21]([CH3:23])[CH3:22])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 4571240tert-Butyl (1-(oxiran-2-yl)-2-phenylethyl)carbamate

Product 1

HCID 21878363(1-Benzyl-2-hydroxy-3-isobutylaminopropyl)carbamic acid tert-butyl ester

Procedure

This compound was synthesized from the commercially available (1-oxiranyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (1), which was reacted with isobutylamine thereby forming the amino alcohol 2.

Sources & evidence

ORD record
ord-3a8ae24def154defbfe3c08ef1dcf2ab
Source dataset
uspto-grants-2010_09
Patent number
US07803836B2

Reaction notes

Loading…