Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluoro-3-nitroaniline → 2,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluoro-3-nitroaniline | HCID 67768 | — |
| 반응물 | 2,4-Difluorobenzoyl chloride | HCID 588081 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide | HCID 9212604 | 84.4% |
반응 단계
Using a method similar to Preparation 13, using 4-fluoro-3-nitroaniline (1.0 g, 6.4 mmol), dioxane (20 mL), and 2,4-difluorobenzoyl chloride (1.46 g, 8.3 mmol) gives the title intermediate (1.6 g, 84% yield): mass spectrum (ion spray): m/z=297.0 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07803813B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-7251dd4e57124d51a15543d798e79f03 |
| 출처 메모 | uspto-grants-2010_09 |