2,6-Diaminopyridine → HCID 58997390, compound

HRID 1716907Notes

Reaction equation

HRID 1716907 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[N:3]=1.[Cl:9][C:10]1[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[C:11]=1[C:12](Cl)=[O:13]>O1CCOCC1>[NH2:8][C:4]1[N:3]=[C:2]([NH:1][C:12](=[O:13])[C:11]2[C:15]([Cl:20])=[CH:16][C:17]([Cl:19])=[CH:18][C:10]=2[Cl:9])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 88612,6-DiaminopyridineHCID 27337032,4,6-Trichlorobenzoyl chloride

Product 1

HCID 58997390HCID 58997390, compoundYield 39.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using a method similar to Preparation 48, using 2,6-diaminopyridine (2.6 g, 12 mmol), dioxane (80 mL), and 2,4,6-trichlorobenzoyl chloride (1.95 g, 8 mmol) (stir at 0-25° C. for 16 hr.) gives the title intermediate (1.0 g, 39% yield): mass spectrum (ion spray): m/z=316.0 (M+1).

Workup

  1. customsimilar to Preparation 48

Sources & evidence

ORD record
ord-d96af7a882204e93b2e3c770ef922d5c
Source dataset
uspto-grants-2010_09
Patent number
US07803813B2

Reaction notes

Loading…