4-Fluorobenzoyl chloride → HCID 66939216, compound

HRID 1716930Notes

Reaction equation

HRID 1716930 reaction equation
[CH3:1][N:2]([CH:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH2:9])[N:4]=1.[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([Cl:24])=[O:23])=[CH:20][CH:19]=1>>[ClH:24].[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([N:2]([CH3:1])[CH:10]3[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]3)[N:4]=2)=[O:23])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 58997271N-methyl N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine

Product 1

HCID 66939216HCID 66939216, compoundYield 90%

Procedure

Prepare according to Example 69 starting with N-Methyl-N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine (Preparation 34) (200 mg, 0.91 mmol) and 4-fluorobenzoyl chloride (160 ut, 1.36 mmol) to yield 309 mg (90%) of the title compound: mass spectrum (ion spray): m/z=343.3 (M+1); Analysis calc'd for C19H24N4OFCl.0.6H2O: C, 58.56; H, 6.52; N, 14.38. Found: C, 58.31; H, 6.37; N, 14.39; mp 250-2° C.

Workup

  1. customPrepare

Sources & evidence

ORD record
ord-2636a4bf501d4d79abfd02855dea8ac0
Source dataset
uspto-grants-2010_09
Patent number
US07803813B2

Reaction notes

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