HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tolylboronic acid → (3-{[5-(4-Methyl-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tolylboronic acid | HCID 79799 | — |
| Reactant | (3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl)-acetic Acid Methyl Ester | HCID 59654700 | — |
| Product | (3-{[5-(4-Methyl-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acetic acid methyl ester | HCID 59654798 | — |
Reaction Steps
Methyl ester (16) (100 mg, 0.30 mmol) was coupled to 4-methyl-phenylboronic acid (44 mg, 0.33 mmol) using Method E. The crude compound was purified by column chromatography, eluting in 17% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803841B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-b7108474ad3344f5b6c504600ef40d69 |
| Source note | uspto-grants-2010_09 |