4-Bromo-2-chlorobenzoic acid → HCID 59654821, compound

HRID 1717028Notes

Reaction equation

HRID 1717028 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([Cl:11])[CH:3]=1.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=2[Cl:11])[CH:18]=1)[CH3:13]

Participants

3

Reactant 2

HCID 1088294-Bromo-2-chlorobenzoic acidHCID 13042040Ethyl 2-(3-aminophenyl)acetate

Product 1

HCID 59654821HCID 59654821, compound

Procedure

4-Bromo-2-chlorobenzoic acid (132 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.

Sources & evidence

ORD record
ord-7347db366a1f48c8bfd36c0c967edb07
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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