5-Bromo-2-fluorobenzoic acid → HCID 59654736, compound

HRID 1717032Notes

Reaction equation

HRID 1717032 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:4](=[O:6])[C:3]2[CH:7]=[C:8]([Br:11])[CH:9]=[CH:10][C:2]=2[F:1])[CH:18]=1)[CH3:13]

Participants

3

Reactant 2

HCID 27363155-Bromo-2-fluorobenzoic acidHCID 13042040Ethyl 2-(3-aminophenyl)acetate

Product 1

HCID 59654736HCID 59654736, compound

Procedure

2-Fluoro-5-bromobenzoic acid (123 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.

Sources & evidence

ORD record
ord-99c72cec31d34e9798498249ce116da4
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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