5-Phenylfuran-2-carboxylic acid → HCID 59654780, compound

HRID 1717064Notes

Reaction equation

HRID 1717064 reaction equation
[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:15][C:16]1[CH:17]=[C:18]([CH2:22][C:23]#[N:24])[CH:19]=[CH:20][CH:21]=1>>[C:23]([CH2:22][C:18]1[CH:17]=[C:16]([NH:15][C:12]([C:10]2[O:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][CH:9]=2)=[O:14])[CH:21]=[CH:20][CH:19]=1)#[N:24]

Participants

3

Reactant 2

HCID 7362555-Phenylfuran-2-carboxylic acidHCID 4847850(3-Amino-phenyl)-acetonitrile

Product 1

HCID 59654780HCID 59654780, compound

Procedure

5-Phenyl-2-furoic acid (56) (223 mg, 1.2 mmol) was coupled to 3-aminophenyl acetonitrile (80) (157 mg, 1.19 mmol), using Method C. The crude residue was purified by column chromatography, eluting in 17% EtOAc in heptane to give the title compound.

Workup

  1. customThe crude residue was purified by column chromatography
  2. washeluting in 17% EtOAc in heptane

Sources & evidence

ORD record
ord-75477e94c64f4b8c930184db284de436
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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