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5-(3-Chlorophenyl)furan-2-carboxylic acid → (3-[5-(3-Chloro-phenyl)-furan-2-carbonyl]-phenyl)-acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(3-Chlorophenyl)furan-2-carboxylic acid | HCID 736256 | — |
| 反応物 | (3-Amino-phenyl)-acetonitrile | HCID 4847850 | — |
| 生成物 | (3-[5-(3-Chloro-phenyl)-furan-2-carbonyl]-phenyl)-acetonitrile | HCID 68490730 | — |
反応手順
Carboxylic acid (65) (127 mg, 0.57 mmol) was coupled to aniline (80) (75 mg, 0.57 mmol) using Method C. The crude residue was purified by column chromatography eluting with 17% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07803841B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-106a8f37cfce4f1c9368d86c11e1fc62 |
| 出典メモ | uspto-grants-2010_09 |