3-Fluorophenylboronic acid → HCID 59654605, compound

HRID 1717079Notes

Reaction equation

HRID 1717079 reaction equation
[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15](Br)[N:14]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)#[N:2].[F:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1>>[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:25]3[CH:24]=[CH:23][CH:22]=[C:21]([F:20])[CH:26]=3)[N:14]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)#[N:2]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 59654866HCID 59654866, compound

Product 1

HCID 59654605HCID 59654605, compound

Procedure

The pyridyl bromide (91) (150 mg, 0.47 mmol) was coupled to 3-fluoro-phenylboronic acid (73 mg, 0.52 mmol) using Method E. The crude residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.

Workup

  1. customThe crude residue was purified by column chromatography
  2. washeluting with 20% EtOAc in heptane

Sources & evidence

ORD record
ord-cfe4d854155b490d857772c103ddd38f
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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