Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluorophenylboronic acid → 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| 반응물 | 3-{3-[(6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 72348809 | — |
| 생성물 | 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68497963 | — |
반응 단계
The pyridyl bromide (109) (100 mg, 0.27 mmol) was coupled to 3-fluoro-phenylboronic acid (41 mg, 0.29 mmol) using Method E. The residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07803841B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-b696dec9d7374275935d6499eaf30da5 |
| 출처 메모 | uspto-grants-2010_09 |