HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenylboronic acid → 4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| Product | 4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid | HCID 46312333 | — |
Reaction Steps
5-Bromo-2-fluorobenzoic acid (250 mg, 1.14 mmol) was coupled to 4-fluoro-phenylboronic acid (192 mg, 1.37 mmol) using Method E to give the title compound. No chromatography was necessary.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803841B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-5cbb45e59c5248a1929554eaa0404118 |
| Source note | uspto-grants-2010_09 |