3-Aminocinnamic acid ethyl ester → HCID 68494747, compound

HRID 1717101Notes

Reaction equation

HRID 1717101 reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.[CH2:10]([O:12][C:13](=[O:23])[CH:14]=[CH:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1)[CH3:11]>>[CH2:10]([O:12][C:13](=[O:23])[CH:14]=[CH:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:7]([C:5]2[N:6]=[C:2]([Cl:1])[S:3][CH:4]=2)=[O:9])[CH:17]=1)[CH3:11]

Participants

3

Reactant 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 218030262-Chloro-1,3-thiazole-4-carboxylic acid

Product 1

HCID 68494747HCID 68494747, compound

Procedure

Carboxylic acid (79) (220 mg, 1.34 mmol) was coupled to aniline (60) (257 mg, 1.34 mmol) using Method C to give the title compound.

Sources & evidence

ORD record
ord-4ecaf9f688ad4424957b4f01e6d991a9
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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