反应详情

The chloro thiazole (114) (80 mg, 0.24 mmol) was coupled to 3-fluoro-phenylboronic acid (42 mg, 0.30 mmol) using Method E, except that the reaction mixture was heated for a total of 12 h. The crude residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.

1. temperatureexcept that the reaction mixture was heated for a total of 12 h
2. customThe crude residue was purified by column chromatography
3. washeluting with 20% EtOAc in heptane