(3-Chlorophenyl)boronic acid → HCID 59654683, compound

HRID 1717123Notes

Reaction equation

HRID 1717123 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17](Br)[N:16]=2)=[O:14])[CH:7]=1)C.[Cl:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1>>[Cl:23][C:24]1[CH:29]=[C:28]([C:17]2[N:16]=[C:15]([C:13]([NH:12][C:8]3[CH:7]=[C:6]([CH2:5][C:4]([OH:3])=[O:22])[CH:11]=[CH:10][CH:9]=3)=[O:14])[CH:20]=[CH:19][CH:18]=2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 59654644HCID 59654644, compound

Product 1

HCID 59654683HCID 59654683, compound

Procedure

The pyridyl bromide (77) (44 mg, 0.12 mmol) was coupled to 3-chloro-phenylboronic acid (20 mg, 0.13 mmol) using Method E. During this reaction, hydrolysis occurred. The residue was extracted using Work-up E1 to give the acid. The solid was further purified by preparative HPLC to give the title compound.

Workup

  1. customDuring this reaction, hydrolysis
  2. extractionThe residue was extracted
  3. customto give the acid
  4. customThe solid was further purified by preparative HPLC

Sources & evidence

ORD record
ord-a052a3a7ffea408f90b05ef1a0c0d676
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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