3-Aminocinnamic acid ethyl ester → Ethyl 3-[3-[[[6-(3,5-dichlorophenyl)-2-pyridinyl]carbonyl]amino]phenyl]-2-propenoate

HRID 1717126Notes

Reaction equation

HRID 1717126 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:15]([C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:14]=2)=[O:17])[CH:25]=1)[CH3:19]

Participants

3

Reactant 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 24730153HCID 24730153, compound

Product 1

HCID 68499249Ethyl 3-[3-[[[6-(3,5-dichlorophenyl)-2-pyridinyl]carbonyl]amino]phenyl]-2-propenoate

Procedure

Carboxylic acid (131) (50 mg, 0.19 mmol) was coupled to aniline (60) (40 mg, 0.21 mmol) using Method D. The residue was triturated with TBME (3 ml) to give the title compound.

Workup

  1. customThe residue was triturated with TBME (3 ml)

Sources & evidence

ORD record
ord-c7ba46ab766b457d93684ce8e4b7373f
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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