4-Chlorophenylboronic acid → 6-(4-Chlorophenyl)picolinic acid

HRID 1717142Notes

Reaction equation

HRID 1717142 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 5939196-Bromopyridine-2-carboxylic acid

Product 1

HCID 247301366-(4-Chlorophenyl)picolinic acid

Procedure

6-Bromo-pyridine-2-carboxylic acid (1 g, 4.95 mmol) was coupled to 4-chloro-phenylboronic acid (775 mg, 4.96 mmol) acid using Method F to give the title compound.

Sources & evidence

ORD record
ord-9dd3a97ffc44446ba4f8f604cc06a1b7
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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