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Phenylboronic Acid → 3-{3-[(6-Phenyl-pyridine-2-carbonyl)-amino]-phenyl}-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | 3-(3-{[6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-propionic acid ethyl ester | HCID 59654822 | — |
| 生成物 | 3-{3-[(6-Phenyl-pyridine-2-carbonyl)-amino]-phenyl}-propionic acid ethyl ester | HCID 59654842 | — |
反応手順
The pyridyl bromide (161) (100 mg, 0.27 mmol) was coupled to phenylboronic acid (30 mg, 0.25 mmol) using Method E. The residue was purified by column chromatography eluting with 15% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07803841B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-1f82eb92fd3444ed96fb430f471dc65f |
| 出典メモ | uspto-grants-2010_09 |