反应详情

To a solution of 1-(4-aminophenyl)-N-cyclopropyl-5-propyl-1H-1,2,3-triazole-4-carboxamide (0.29 g) obtained in Example 1d) in dichloromethane (10 ml) was added propionyl chloride (0.09 ml) under ice-cooling, and the mixture was stirred for 1 hr. The reaction mixture was diluted with dichloromethane, and washed with saturated aqueous sodium hydrogen carbonate solution. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column (ethyl acetate/hexane=1/4 to 1/1) to give the title compound as a white powder (0.11 g, 31%).

1. temperaturecooling
2. washwashed with saturated aqueous sodium hydrogen carbonate solution
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by silica gel column (ethyl acetate/hexane=1/4 to 1/1)