Diethyl Ether → HCID 68514324, compound

HRID 1717236Notes

Reaction equation

HRID 1717236 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][CH2:14][CH3:15])=[C:11]([C:16]([NH:18][CH:19]3[CH2:21][CH2:20]3)=[O:17])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[C:22]1(=[O:28])[O:27][C:25](=[O:26])[CH2:24][CH2:23]1.C(OCC)C>C(Cl)(Cl)Cl>[CH:19]1([NH:18][C:16]([C:11]2[N:10]=[N:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([NH:1][C:22](=[O:28])[CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:3][CH:4]=3)[C:12]=2[CH2:13][CH2:14][CH3:15])=[O:17])[CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 7922Succinic anhydrideHCID 685175481-(4-aminophenyl)-N-cyclopropyl-5-propyl-1H-1,2,3-triazole-4-carboxamide

Product 1

HCID 68514324HCID 68514324, compoundYield 51,929.602%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 1-(4-aminophenyl)-N-cyclopropyl-5-propyl-1H-1,2,3-triazole-4-carboxamide (0.14 g) obtained in Example 1d) in chloroform (10 ml) was added succinic anhydride (0.06 mg), and the mixture was stirred at room temperature for 3 days. Diethyl ether was added to the reaction mixture, and the precipitated crystals were collected by filtration and washed with diethyl ether to give the title compound as a pale-brown powder (0.12 g, 63%).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-9384b7371ebe45fab9d4495652c7ec17
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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