Ethyl isocyanate → HCID 11849858, compound

Participants

Reaction Steps

To a solution of 1-(4-aminophenyl)-N-cyclopropyl-5-propyl-1H-1,2,3-triazole-4-carboxamide (0.40 g) obtained in Example 1d) and DMAP (0.34 g) in dichloromethane (14 ml) was added ethyl isocyanate (0.79 ml) at room temperature and the mixture was stirred for 3 hr. The reaction mixture was diluted with dichloromethane, and washed with saturated aqueous sodium hydrogen carbonate solution. The organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column (ethyl acetate/hexane=1/1 to ethyl acetate), and the obtained product was recrystallized from ethyl acetate-diethyl ether to give the title compound as a white powder (0.12 g, 49%).

Provenance & Evidence