Acetone → HCID 57665028, compound

Participants

Reaction Steps

To a solution of 5-(3-buten-1-yl)-N-cyclopropyl-1-(4-{[(ethylamino)carbonyl]amino}phenyl)-1H-1,2,3-triazole-4-carboxamide obtained in Example 41 in acetone (3 ml)-acetonitrile (3 ml)—water (3 ml) were added N-methylmorpholine N-oxide (0.18 g) and microencapsulated osmium tetroxide (containing 10%, 0.5 g). The reaction mixture was stirred at room temperature for 4 days, and the insoluble material was filtered off. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (ethyl acetate/methanol=9/1 to ethyl acetate/methanol=7/3). The resultant product was recrystallized from ethyl acetate/hexane to give the title compound as colorless crystals (0.12 g, 23%).

Provenance & Evidence