Sodium Carbonate → HCID 68514328, compound

Participants

Reaction Steps

1-(4-{[(2-Phenylethyl)amino]carbonyl}phenyl)-5-propyl-1H-1,2,3-triazole-4-carboxylic acid (510 mg, 1.35 mmol) obtained in Example 59b), HOBt (92 mg, 0.674 mmol, 0.5 eq.) and cyclopropylamine (0.125 ml, 1.75 mmol, 1.3 eq.) were dissolved in acetonitrile-DMF (2:1, 9.0 ml), WSC (316 mg, 1.62 mmol, 1.2 eq.) was added, and the mixture was stirred at room temperature for 2 hr. 2% Aqueous sodium carbonate solution (10 ml) was added to the reaction mixture and the mixture was stirred at room temperature for 1 hr. The precipitate was collected by filtration, washed with ice-cold water and dried to give a grayish white powder. This was crystallized from methanol-diethyl ether to give the title compound as a white powder (421 mg, 1.01 mmol, 74.7%).

Provenance & Evidence