Potassium Carbonate → 4-azido-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

4-Azido-N-(2-bromoethyl)benzamide (2.0 g) obtained in Example 63a) and potassium carbonate (1.34 g, 9.70 mmol, 1.0 eq.) were suspended in acetonitrile (40 ml), N-methylpiperazine (1.63 ml, 14.6 mmol, 1.5 eq.) was added, and the mixture was stirred at room temperature for 16 hr and at 75° C. for 7 hr. The reaction mixture was concentrated, diluted with water (40 ml) and washed with ethyl acetate-hexane (2:1, 50 ml). The organic layer was extracted twice with water (20 ml). The aqueous layers were combined, concentrated, saturated with sodium chloride and extracted with ethyl acetate (40 ml and 30 ml). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated at 30° C. or below to give the title compound as a pale-yellow solid (0.69 g, 2.39 mmol, 24.7%).

Herkunft & Nachweise